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Founded in the 1820s as a planned manufacturing center for textiles, Lowell is located along the rapids of the Merrimack River, 25 mi (40 km) northwest of Boston in what was once the farming community of East Chelmsford, Massachusetts. The so-called Boston Associates, including Nathan Appleton and Patrick Tracy Jackson of the Boston Manufacturing Company, named the new mill town after their visionary leader, Francis Cabot Lowell, who had died five years before its 1823 incorporation. As Lowell’s population grew, it acquired land from neighboring towns, and diversified into a full-fledged urban center. Many of the men who composed the labor force for constructing the canals and factories had immigrated from Ireland, escaping the poverty and Great Famine of the 1830s and 1840s. The mill workers, young single women called Mill Girls, generally came from the farm families of New England.

By the 1850s, Lowell had the largest industrial complex in the United States. The textile industry wove cotton produced in the Southern United States. In 1860, there were more cotton spindles in Lowell than in all eleven states combined that would form the Confederate States of America. Many of the coarse cottons produced in Lowell eventually returned to the South to clothe enslaved people, and, according to historian Sven Beckert, “‘Lowell’ became the generic term slaves used to describe coarse cottons.” The city continued to thrive as a major industrial center during the 19th century, attracting more migrant workers and immigrants to its mills. Next were the Catholic Germans, followed by a large influx of French Canadians during the 1870s and 1880s. Later waves of immigrants came to work in Lowell and settled in ethnic neighborhoods, with the city’s population reaching almost 50% foreign-born by 1900. By the time World War I broke out in Europe, the city had reached its economic peak.

In 1922, it was affected by the 1922 New England Textile Strike, shutting down the mills in the city over an attempted wage cut.